Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. SDS of cas: 766-11-0.
Ran, Fansheng;Liu, Yang;Yu, Shengping;Guo, Kaiwen;Tang, Wendi;Chen, Xin;Zhao, Guisen research published 《 Design and synthesis of novel 1-substituted 3-(6-phenoxypyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine analogs as selective BTK inhibitors for the treatment of mantle cell lymphoma》, the research content is summarized as follows. Ibrutinib (IBN), a first-in-class BTK-inhibitor, was approved by the FDA for the treatment of mantle cell lymphoma (MCL). Although IBN shows excellent performance as an anti-lymphoma agent, it has some undesirable side effects due to its off-target activities. Herein, a novel series of 3-(6-phenoxypyridin-3-yl)-4-amine-1H-pyrazolo[3,4-d]pyrimidine derivatives I (R1 = H, F; R2 = H, Cl, F, CF3; R3 = H, Me, CN, etc.; n = 0, 1, 2), II (R4 = COCH2OH, COH2C(CH3)OH, COHC(CH3)2CH2OH, CO(CH2)2OMe, COCH2Cl) capable of potent inhibition of Bruton’s tyrosine kinase (BTK) is reported. Notably, compound II (R4 = COCH2Cl) explained potent BTK inhibitory activity and could completely inhibit the phosphorylation of BTK and PLCγ2 in Z138 cells at low micromolar concentration Compared with IBN, the above compound improved anti-proliferative activities 3-40 folds in MCL cell lines with IC50 values lower than 1μM. Low micromolar doses of compound II (R4 = COCH2Cl) could induce strong cell apoptosis in Jeko-1 and Z138 cells and in addition, it showed greater BTK selectivity and higher stability in human liver microsomes than IBN and potential safety improvement for the treatment of MCL.
SDS of cas: 766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.