Related Products of 113770-88-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.113770-88-0, name is 3-Fluoro-4-cyanopyridine, molecular formula is C6H3FN2, molecular weight is 122.1, as common compound, the synthetic route is as follows.
3-Fluoroisonicotinonitrile (CAS ii3770-88-0, 68.4 mg, 0.56 mmol) and tert-butyl piperazinei-carboxylate (CAS 76535-74-5, 2i9 mg, i.i8 mmol) were dissolved in toluene in a microwave vial before flushed with Ar(g) and heated in a microwave reactor for is mm atiOOC. The reaction was diluted with EtOAc and filtered through a plug of silica. The filtrate was reduced in vacuo to give tert-butyl 4-(4-cyanopyridin-3-yl)piperazine-i-carboxylate (i53 mg, 95%).MS (ESI) m/z i89.0 [(M-Boc)-i-H]
Statistics shows that 113770-88-0 is playing an increasingly important role. we look forward to future research findings about 3-Fluoro-4-cyanopyridine.
Reference:
Patent; ACTURUM LIFE SCIENCE AB; SVENSSON, Mats A; WEIGELT, Dirk; WO2014/184248; (2014); A2;,
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