Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Computed Properties of 31181-90-5.
Scott, James S.;Moss, Thomas A.;Balazs, Amber;Barlaam, Bernard;Breed, Jason;Carbajo, Rodrigo J.;Chiarparin, Elisabetta;Davey, Paul R. J.;Delpuech, Oona;Fawell, Stephen;Fisher, David I.;Gagrica, Sladjana;Gangl, Eric T.;Grebe, Tyler;Greenwood, Ryan D.;Hande, Sudhir;Hatoum-Mokdad, Holia;Herlihy, Kara;Hughes, Samantha;Hunt, Thomas A.;Huynh, Hoan;Janbon, Sophie L. M.;Johnson, Tony;Kavanagh, Stefan;Klinowska, Teresa;Lawson, Mandy;Lister, Andrew S.;Marden, Stacey;McGinnity, Dermot F.;Morrow, Christopher J.;Nissink, J. Willem M.;O’Donovan, Daniel H.;Peng, Bo;Polanski, Radoslaw;Stead, Darren S.;Stokes, Stephen;Thakur, Kumar;Throner, Scott R.;Tucker, Michael J.;Varnes, Jeffrey;Wang, Haixia;Wilson, David M.;Wu, Dedong;Wu, Ye;Yang, Bin;Yang, Wenzhan research published 《 Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist》, the research content is summarized as follows. Herein we report the optimization of a series of tricyclic indazoles as selective estrogen receptor degraders (SERD) and antagonists for the treatment of ER+ breast cancer. Structure based design together with systematic investigation of each region of the mol. architecture led to the identification of N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine (I). This compound was demonstrated to be a highly potent SERD that showed a pharmacol. profile comparable to fulvestrant in its ability to degrade ERα in both MCF-7 and CAMA-1 cell lines. A stringent control of lipophilicity ensured that I had favorable physicochem. and preclin. pharmacokinetic properties for oral administration. This, combined with demonstration of potent in vivo activity in mouse xenograft models, resulted in progression of this compound, also known as AZD9833, into clin. trials.
Computed Properties of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.
5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.