Application of 52833-94-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52833-94-0, name is 2-Amino-5-bromonicotinic acid, molecular formula is C6H5BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2-Amino-5-bromo-nicotinic acid (1 g, 4.61 mmol) and SOd2 (5 mL) in toluene (15 mE) was stirred at 130C for 2 h. After concentrated, the residue was dissolved in tetrahydrofuran (20 mE), and then 2-fluoro-phenylamine (1.09 g, 9.81 mmol) was added dropwise at 0C. The reaction mixture was heated to 90C for 4 h. After being cooled to room temperature andquenched with saturated aqueous K2C03 (10 mE), the mixture was extracted with ethyl acetate (50 mE * 3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified with silica gel column chromatograph (PE : EtOAc = 2: 1) to give 2-amino-5-bromo-N-(2-fluorophenyl) nicotinamide (1.0 g, 70 % yield). as yellow solid. ?H-NMR (CDC13, 400 MHz) 8.258.28 (m, 2H), 7.86 (d, J 2.4 Hz, 2H), 7.137.22 (m, 3H), 6.36 (s, 2H). MS (M+H): 311 /313.
According to the analysis of related databases, 52833-94-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); A1;,
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