Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Computed Properties of 16133-25-8.
Su, Shijun;Zhou, Qing;Tang, Xuemei;Peng, Feng;Liu, Tingting;Liu, Liwei;Xie, Chengwei;He, Ming;Xue, Wei research published 《 Design, synthesis, and antibacterial activity of novel myricetin derivatives containing sulfonate》, the research content is summarized as follows. A series of myricetin derivatives containing sulfonate groups I (R = Ph, 2-chlorophenyl, 2-thienyl, etc.) was designed and synthesized. Preliminary antibacterial activity showed that most of the target compounds I exhibited significant biol. activities against Xanthomonas axonopodis pv. In particular, the EC50 value of compound I (R = 4-nitrophenyl) was 13.76μg/cm3 against Xac, which was better than com. reagents bismerthiazol (50.32μg/cm3) and thiodiazole copper. (83.27μG/cm3), and the EC50 value of compound I (3-chlorophenyl) was 11.92μg/cm3 against Xoo in vitro and the result was better than that of bismerthiazol (72.08μg/cm3) and thiodiazole copper (99.26μg/cm3). Compound I (R = 3-chlorophenyl) displayed the better in vivo activity against rice bacterial leaf blight than bismerthiazol and thiodiazole copper. Meanwhile, the antibacterial mechanism of compounds I (R = 4-nitrophenyl) and I (R = 3-chlorophenyl) was studied by scanning electron microscope (SEM). These results suggested that myricetin derivatives containing sulfonate I can be considered as new antibacterial reagents.
16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Computed Properties of 16133-25-8