Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Product Details of C6H4BrNO.
Wang, Yanyan;Xu, Fangzhou;Luo, Dexia;Guo, Shengxin;He, Feng;Dai, Ali;Song, Baoan;Wu, Jian research published 《 Synthesis of Anthranilic Diamide Derivatives Containing Moieties of Trifluoromethylpyridine and Hydrazone as Potential Anti-Viral Agents for Plants》, the research content is summarized as follows. A series of novel anthranilic diamide derivatives I (R = 4-Cl-2-Me, 4,6-di-F, 6-Me, etc.; Ar = thiophen-2-yl, 5-bromopyridin-2-yl, iso-Pr, etc.) containing moieties of trifluoromethylpyridine and hydrazone was synthesized and evaluated in vivo for their activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). Few compounds had the curative activity over 65% against TMV at the concentration of 500 μg/mL, which were significantly higher than those of ningnanmycin (55.0%) and ribavirin (37.9%). Notably, the curative activity of compound I (R = 4-Cl-2-Me, Ar = 5-Me-thien-2-yl) was up to 79.5%, with the EC50 value of 75.9 μg/mL, whereas the EC50 value of ningnanmycin was 362.4 μg/mL and pot experiments also further demonstrated the significantly curative effect of the compound Meanwhile, few compounds displayed more protective activities on TMV than that of ningnanmycin. Moreover few, compounds showed inactivation activity similar to ningnanmycin at 500 μg/mL, and the EC50 value of I (R = 4-Cl-2-Me, Ar = 2-CH3C6H4) (41.5 μg/mL) was lower than ningnanmycin (50.0 μg/mL). The findings of TEM indicated that the synthesized compounds exhibited strong and significant binding affinity to TMV coat protein (CP) and could obstruct the self-assembly and increment of TMV particles. Microscale thermophoresis (MST) studies on TMV-CP and CMV CP revealed that some of the active compounds, particularly I (R = 4-Cl-2-Me, Ar = 5-Me-thien-2-yl) exhibited a strong binding capability to TMV-CP or CMV-CP.
Product Details of C6H4BrNO, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.
5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.