Reference of 1603-40-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1603-40-3, name is 3-Methylpyridin-2-amine. A new synthetic method of this compound is introduced below.
2.4.1 Synthesis of 2-(3-methylpyridin-2-yl)isoindoline-1,3-dione (1) To a solution of phthalic anhydride (7.00 g, 47.26 mmol) in toluene (250 mL) was added 2-amino-3-picoline (5.11 g, 47.26 mmol) followed by triethylamine (5 mL). The mixture was refluxed under a Dean-Stark trap for 48 h. The cold colorless solution was evaporated and the residue was recrystallized from ethanol (60 mL) as white crystalline solid. Yield: (8.71 g, 77%). M.p.: 162-164 C. Anal. Calc. for C14H10N2O2: C, 70.58; H, 4.20; N, 11.76. Found: C, 70.21; H, 4.07; N, 11.55%. IR (cm-1) = 840 w (nu C-N), 1708 s (nus C=O), 1762 m (nuas C=O), 2871, 2920 s (nus CH2). 1H NMR (300 MHz, CDCl3): delta (ppm) = 2.21 (s, 3H, CH3), 7.23-8.42 (m, 7H, Ar-H). 13C NMR (75 MHz, CDCl3): delta (ppm) = 17.52 (CH3), 123.91-147.48 (Ar-C), 166.33 (C=O).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1603-40-3, 3-Methylpyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Article; Singh, Gurjaspreet; Saroa, Amandeep; Girdhar, Shally; Rani, Sunita; Sahoo, Subash; Choquesillo-Lazarte, Duane; Inorganica Chimica Acta; vol. 427; (2015); p. 232 – 239;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem