In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14667-47-1, name is Methyl 2-aminonicotinate, the common compound, a new synthetic route is introduced below. Quality Control of Methyl 2-aminonicotinate
Concentrated nitric acid (65%, 3.2 mmol, 76 mmol, 1.05 equiv) was added dropwise to a stirred suspension of 21 (10.0 g, 72.4 mmol) in concentrated sulfuric acid (96%, 90.5 mL, 1.69 mol, 23.3 equiv) maintained at 0 C.The solution was brought back to room temperature and stirred for 2 h. The brown mixture was poured onto iced water and carefully quenched by adding solid Na2CO3 portionwise until complete neutralization (pH>8). The aqueous layerwas extracted three times with AcOEt. The combined organic layers were washed with brine and water, and dried over MgSO4. Evaporation of the residue in vacuo furnished the title compound 22 in analytically pure form(11.7 g, 82%) as a colourless solid
The synthetic route of 14667-47-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hedou, Damien; Deau, Emmanuel; Harari, Marine; Sanselme, Morgane; Fruit, Corinne; Besson, Thierry; Tetrahedron; vol. 70; 35; (2014); p. 5541 – 5549;,
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