At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Reference of 766-11-0.
White, Catherine;McGowan, Meredeth A.;Zhou, Hua;Sciammetta, Nunzio;Fradera, Xavier;Lim, Jongwon;Joshi, Elizabeth M.;Andrews, Christine;Nickbarg, Elliott B.;Cowley, Phillip;Trewick, Sarah;Augustin, Martin;von Koenig, Konstanze;Lesburg, Charles A.;Otte, Karin;Knemeyer, Ian;Woo, Hyun;Yu, Wensheng;Cheng, Mangeng;Spacciapoli, Peter;Geda, Prasanthi;Song, Xuelei;Smotrov, Nadya;Curran, Patrick;Heo, Mee Ra;Abeywickrema, Pravien;Miller, J. Richard;Bennett, David Jonathan;Han, Yongxin research published 《 Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1)》, the research content is summarized as follows. Indoleamine-2,3-dioxygenase-1 (IDO1) has emerged as a target of significant interest to the field of cancer immunotherapy, as the upregulation of IDO1 in certain cancers has been linked to host immune evasion and poor prognosis for patients. In particular, IDO1 inhibition is of interest as a combination therapy with immune checkpoint inhibition. Through an Automated Ligand Identification System (ALIS) screen, a diamide class of compounds was identified as a promising lead for the inhibition of IDO1. While hit 1() possessed attractive cell-based potency, it suffered from a significant right-shift in a whole blood assay, poor solubility, and poor pharmacokinetic properties. Through a physicochem. property-based approach, including a focus on lowering AlogP98 via the strategic introduction of polar substitution, compound 13 was identified bearing a pyridyl oxetane core. Compound 13() demonstrated improved whole blood potency and solubility, and an improved pharmacokinetic profile resulting in a low predicted human dose.
766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Reference of 766-11-0