The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Category: pyridine-derivatives.
Zhang, Lin;Yamazaki, Ken;Leitch, Jamie A.;Manzano, Ruben;Atkinson, Victoria A. M.;Hamlin, Trevor A.;Dixon, Darren J. research published 《 Dual catalytic enantioselective desymmetrization of allene-tethered cyclohexanones》, the research content is summarized as follows. The construction of enantioenriched azabicyclo[3.3.1]nonan-6-one heterocycles I [R = H, Ph, prop-2-en-1-yl, benzyl, etc.; X = O, 4-H3CC6H4S(O)2NH, NHS(O)2Me, etc.] via an enantioselective desymmetrization of allene-linked cyclohexanones II, enabled through a dual catalytic system, that provides synchronous activation of the cyclohexanone with a chiral prolinamide and the allene with a copper(I) co-catalyst to deliver the stereodefined bicyclic core, is described. Successful application to oxygen analogs was also achieved, thereby providing a new enantioselective synthetic entry to architecturally complex bicyclic ethereal frameworks. The mechanistic pathway and the origin of enantio- and diastereoselectivities have been uncovered using d. functional theory (DFT) calculations
Category: pyridine-derivatives, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.