On January 29, 2015, Le Tiran, Arnaud; Le Diguarher, Thierry; Starck, Jerome-Benoit; Henlin, Jean-Michel; De Nanteuil, Guillaume; Geneste, Olivier; Davidson, James Edward Paul; Murray, James Brooke; Chen, I-Jen published a patent.Synthetic Route of 908267-63-0 The title of the patent was New indolizine carboxamide derivatives, their preparation as pro-apoptotic and antitumor agents and their pharmaceutical compositions containing them. And the patent contained the following:
Indolizine and indolizine derivatives, especially 5,6,7,8-tetrahydroindolizine optionally substituted with an NH2 group, 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine optionally substituted with a Me group and pyrrolo[1,2-a]pyrimidine derivatives, e.g., I•HCl, were prepared as inducers of caspase activity and apoptosis for treating neoplasm. Thus, I•HCl was prepared by a multi-step procedure starting from II (preparation given) and (3R)-3-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (preparation given). I•HCl was evaluated for its ability to induce caspase activity and therefore apoptosis in vitro and in vivo and for its ability to inhibit the Bcl-2 protein. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Synthetic Route of 908267-63-0
The Article related to indolizine preparation antitumor proapoptotic agent inducer caspase activity apoptosis, pyrrolopyrazine pyrrolopyrimidine indolizine carboxamide preparation antitumor proapoptotic agent and other aspects.Synthetic Route of 908267-63-0