Pham, Ngoc H.; Wenzel, Thomas J. published an article in 2011, the title of the article was A sulfonated calix[4]resorcinarene with α-methyl-L-prolinylmethyl groups as a water-soluble chiral NMR solvating agent.Category: pyridine-derivatives And the article contains the following content:
A water-soluble calix[4]resorcinarene containing α-methyl-L-prolinylmethyl groups was investigated as a chiral NMR solvating agent. Substrates form complexes by insertion of the aromatic ring into the cavity of the calix[4]resorcinarene. Amino acid derivatives with Ph or indole rings, ammonium substrates with pyridyl, indane or dihydroindole rings, and phenyl-containing substrates with carboxylic acid and/or hydroxyl groups were studied. The effectiveness of the α-methyl-L-prolinylmethyl calix[4]resorcinarene is compared to similar reagents with proline and hydroxyproline moieties that have previously been reported. The α-methyl-L-prolinylmethyl derivative causes larger enantiomeric discrimination of one or more 1H resonances than the previous systems for most of the substrates. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives
The Article related to chiral nmr solvating agent sulfonated calixarene prolinylmethyl derivative, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Category: pyridine-derivatives