On August 7, 2014, Cammarano, Carolyn Michele; Christopher, Matthew P.; Dinsmore, Christopher; Doll, Ronald J.; Fradera Llinas, Francesc Xavier; Li, Chaomin; Machacek, Michelle; Martinez, Michelle; Nair, Latha G.; Pan, Weidong; Reutershan, Michael Hale; Shizuka, Manami; Steinhuebel, Dietrich P.; Sun, Binyuan; Thompson, Christopher Francis; Trotter, B. Wesley; Voss, Matthew Ernst; Wang, Yaolin; Yang, Liping; Panda, Jagannath; Kurissery, Anthappan Tony; Bogen, Stephane L. published a patent.COA of Formula: C8H10BrN The title of the patent was 2,6,7,8-Substituted purines as HDM2 inhibitors and their preparation and use in the treatment of cancer. And the patent contained the following:
The invention provides 2,6,7,8-substituted purines of formula I or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. Compounds of formula I wherein R1 is (un)substituted C1-6 alkyl, 5- to 6-membered nitrogen containing heteroaryl, heterocyclic ring, heterocyclenyl, etc.; R2 is (un)substituted aryl, heteroaryl, C3-8 cycloalkyl, etc.; R3 is C2-6 alkenyl, T-aryl, T-heteroaryl, etc.; R4 is C1-6 alkyl, (CRa2)0-2aryl, (CRa2)0-2heteoaryl, etc.; Ra is H, NH2, halo, etc.; T is C2-4 alkenyl, C=CH2, C=NH, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their HDM2 inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 11.44 nM. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).COA of Formula: C8H10BrN
The Article related to purine preparation hdm2 inhibitor, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.COA of Formula: C8H10BrN