Adding a certain compound to certain chemical reactions, such as: 100-48-1, Isonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H4N2, blongs to pyridine-derivatives compound. Computed Properties of C6H4N2
General procedure: To a stirred suspension of corresponding nitrile and hydroxylamine hydrochloride (1.5 equiv.) in EtOH (10 mL per gram of nitrile) a NaHCO3 (1.5 equiv.) was added. The reaction mixture was stirred under reflux for a 6 h. After the reaction had completed, the reaction mixture was concentrated under reduced pressure, and the residue was diluted with cold water (200 mL). The resulting precipitate was filtered off and washed with cold water (50 mL). N’-Hydroxyisonicotinimidamide (AM-1). Compound was synthesized by following GP1 starting from isonicotinonitrile (10 g, 0.1 mol) in 85% (11.6 g) yield
At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-48-1, Isonicotinonitrile, and friends who are interested can also refer to it.
Reference:
Article; Geyl, Kirill; Baykov, Sergey; Tarasenko, Marina; Zelenkov, Lev E.; Matveevskaya, Vladislava; Boyarskiy, Vadim P.; Tetrahedron Letters; vol. 60; 40; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem