Related Products of 1008-91-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1008-91-9, name is 1-(Pyridin-4-yl)piperazine, molecular formula is C9H13N3, molecular weight is 163.22, as common compound, the synthetic route is as follows.
General procedure: To the stirred solution of 1-phenyl-9H-pyrido [3,4-b]indole-3-carboxylic acid 5 (0.29 g, 0.001 mol) in dry THF, HOBt (0.16 g,0.012 mol) and EDC. HCl (0.23 g, 0.012 mol) were added andcontinued stirring for 30 min. To the reaction mixture, substitutedphenyl piperazine (6a-p) (0.001 mol) was added under ice coldtemperature and the reaction mixture was further stirred at roomtemperature for 6 h. After completion of reaction as monitored byTLC, solvent was evaporated under vacuum. Reaction mixture wasextracted with ethyl acetate (2 20 mL), collected organic layerwas dried over anhydrous Na2SO4, concentrated under vacuum andpassed through small bed of silica gel (60e120) using mobile phase(ethyl acetate: hexane; 3:7) to obtain analytically pure final product7.
Statistics shows that 1008-91-9 is playing an increasingly important role. we look forward to future research findings about 1-(Pyridin-4-yl)piperazine.
Reference:
Article; Ashok, Penta; Chander, Subhash; Smith, Terry K.; Sankaranarayanan, Murugesan; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 559 – 566;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem