On May 11, 2018, Crowley, Brendan M.; Bell, Ian M.; Harvey, Andrew John; Campbell, Brian T.; Greshock, Thomas J.; Rada, Vanessa L. published a patent.Product Details of 908267-63-0 The title of the patent was Preparation of substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors. And the patent contained the following:
The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer’s disease, Parkinson’s disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation. Compounds of formula I wherein X is SONH2 and derivatives, OSONH2 and derivatives, SO2H and SO2-C1-4 alkyl; Y is from 1 to 4 substituents and each are independently H, (un)substituted C1-4 alkyl, halo and OH; A is substituted 6-membered aryl and heteroaryl; R3 and R4 are independently H, halo and (un)substituted C1-4 alkyl; R3R4 can be taken together to form (un)substituted cyclopropyl, (un)substituted cyclobutyl, (un)substituted cyclopentyl and (un)substituted cyclohexyl; R5 and R6 are independently H and C1-4 alkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclization of (1R,3R)-2,2-dimethyl-3-(4-sulfamoylphenyl)cyclopropanecarboximidamide with 3-(dimethylamino)-1-[5-(trifluoromethyl)pyridin-3-yl]prop-2-en-1-one. The invention compounds were evaluated for their α7 nAChR modulatory activity (some data given). The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Product Details of 908267-63-0
The Article related to heteroaryl phenylcyclopropane preparation nicotinic acetylcholine receptor modulator allosteric modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 908267-63-0