Synthetic Route of 13472-85-0, Adding some certain compound to certain chemical reactions, such as: 13472-85-0, name is 5-Bromo-2-methoxypyridine,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13472-85-0.
1.57 g K2CO3, 6.25 ml DMF was added sequentially to a flask equipped with a thermometer, a constant pressure dropping funnel,Stirring in a 100 ml three-necked flask, stirring, 1.41 ml of 5-bromo-2-methoxypyridine slowly,After completion of the dropwise addition, 2.07 g of bisulfonamide was slowly added and the mixture was stirred for 2 hours.Add 1.7 g of 2-chloropyridine stirring reaction 3 hours, diluted with water, stirring 20 min, liquid;The aqueous phase was extracted with ethyl acetate, the organic phases were combined, washed twice with saturated brine,Concentrated under reduced pressure to give a piranone intermediate yellow oil with a purity of 83% and a yield of 85%.
According to the analysis of related databases, 13472-85-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Venturefarm Biotech Corp.; Chen, Mengnan; Zhao, Guolei; (4 pag.)CN105906557; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem