On August 19, 2002, Owa, Takashi; Yoshino, Hiroshi; Okauchi, Tatsuo; Okabe, Tadashi; Ozawa, Yoichi; Hata Sugi, Naoko; Yoshimatsu, Kentaro; Nagasu, Takeshi; Koyanagi, Nozomu; Kitoh, Kyosuke published an article.Computed Properties of 636-73-7 The title of the article was Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents. And the article contained the following:
The synthesis and antitumor activity of E7070 analogs containing a 3-pyridinesulfonamide moiety is reported. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clin. trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogs examined, ER-35745 (I), a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7
The Article related to pyridinesulfonamide indolyl derivative preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 636-73-7