On April 15, 2021, Flohr, Alexander; Eidam, Olive; Fasching, Bernhard; Meniconi, Mirco; Sadok, Amine; Chopra, Rajesh; Zhuai Wang, Hannah; Caldwell, John Jamieson; Collins, Ian; Ryckmans, Thomas published a patent.Recommanded Product: 39919-70-5 The title of the patent was Isoindolinone compounds as cereblon inhibitors and GSPT1 degraders and their preparation. And the patent contained the following:
Disclosed herein is a compound of formula I or pharmaceutically acceptable salts or stereoisomers thereof. Compounds of formula I wherein X1 is (un)branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl-C3-6 cycloalkyl, C6-10 aryl, 5- to 10-membered heteroaryl, etc.; X2 is H, C6-10 aryl, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 4- to 8-membered heterocycloalkyl, etc.; n is 0, 1 and 2; and pharmaceutically acceptable salts, and stereoisomers thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their cereblon inhibitory activity and GSPT1 degradation activity. From the assay, it was determined that compound II exhibited IC50 value of 1037 nM and a DC50 value of > 300 nM. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Recommanded Product: 39919-70-5
The Article related to isoindolinone preparation cereblon inhibitor gspt1 degrader, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 39919-70-5