Raghu, M. S.; Basavaiah, K. published an article in 2012, the title of the article was Rapid and Sensitive Extraction-Free Spectrophotometric Methods for the Determination of Pheniramine Maleate Using Three Sulphonthalein Dyes.Formula: C20H24N2O4 And the article contains the following content:
Three extraction-free spectrophotometric methods which are simple, selective and sensitive are described for the quantitation of pheniramine maleate (PAM), an antiallergic drug, in pure form and in its formulations. The methods are based on formation of yellow colored ion-pair complexes between PAM and 3 sulfonthalein dyes viz., bromothymol blue (method A), and bromocresol purple (method B) in dichloromethane, and bromocresol green (method C) in chloroform medium. The exptl. variables such as reagent concentration, solvent medium and reaction time were carefully optimized to achieve the highest sensitivity. Beer’s law is obeyed over the concentration ranges 1.0-16.0 for method A and method B, and 0.6-12 μg ml-1 PAM for method C with correlation coefficient of 0.999 for method A and method B, and 0.997 for method C. The molar absorptivity values are calculated to be 2.3 × 104, 2.5 × 104 and 3.0 × 104 l mol-1 cm-1 for the methods in the same order. The composition of the ion-pairs was found to be 1:1 by Job’s method of continuous variations and the conditional stability constant (K f) of the complexes were calculated The proposed methods were applied successfully to the determination of PAM in tablets and injection with good accuracy and precision and without interferences from common additives. The results obtained by the proposed methods were compared favorably with those of the reference method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Formula: C20H24N2O4
The Article related to pheniramine maleate determination spectrophotometry bromothymol blue bromocresol purple green, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Formula: C20H24N2O4