On November 30, 2013, Raghu, M. S.; Basavaiah, K.; Abdulrahaman, Sameer A. M.; Prashanth, K. N.; Vinay, K. B. published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Sensitive and selective spectrophotometric methods for the determination of pheniramine maleate in bulk drug and in its formulations using sodium hypochlorite. And the article contained the following:
Two simple, selective and sensitive spectrophotometric methods for the determination of pheniramine maleate (PAM; H1 histamine receptor antagonist) in pharmaceutical pure and dosage forms are described. The methods are based on the reaction of PAM with Na hypochlorite in Kolthoff phosphate-borate buffer pH 7.0 leading to the PAM chloro derivative, subsequent decomposition of excess hypochlorite by Na nitrite (the PAM chloro derivative is not affected under optimized conditions), followed by the oxidation of K iodide with the PAM chloro derivative to iodine (I3-) colored product, which is measured either directly at 355 (method A; yellow product) or after reaction with starch at 590 nm (method B; blue product). The optimal conditions for the PAM-hypochlorite reaction were detd; under these conditions the linear relationship was found in the concentration ranges of 2-50 and 1-25 μg PAM/mL with methods A and B, resp. The calculated molar absorptivity values were 7.26 × 103 and 1.28 × 104 L/(mol cm) for methods A and B, resp. Sandell sensitivity values, limits of detection (LOD), and limits of quantification (LOQ) were calculated The proposed methods were used for the determination of PAM in tablets and injection solutions with good accuracy and precision and without interferences from common pharmaceutical additives. The obtained results compared favorably with those of the reference method. The accuracy and reliability of the proposed methods were further checked by recovery studies via standard addition procedure. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate
The Article related to pharmaceutical analysis pheniramine maleate spectrophotometry sodium hypochlorite reagent, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate