Caglar, Hatice; Bueyuektuncel, Ebru published an article in 2014, the title of the article was HPLC method development and validation: simultaneous determination of active ingredients in cough and cold pharmaceuticals.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:
Objective: This study aimed to develop a simple reversed-phase high performance chromatog. method for simultaneous determination of pseudoephdrine HCI, pheniramine maleate, acetaminophen, guaifenisin, pyrilamine maleate, chlorpheniramine maleate, triprolidine HCI, dextromethorphan HBr, diphenhydramine HCI in cough and cold pharmaceuticals. Methods: The separation of these compounds was achieved within 37.9 min on a Nucleodur gravity C18 column (250 x 4.0 mm, 5μm). The chromatog. separation of these compounds performed in a single run by using isocratic mobile phase consisting of methanol:buffer mixture (38:62, volume/volume) at room temperature, with flow rate of 0.75 mL.min-1. An UV absorption at 210 nm was monitored. 2,4,6-trimethoxybenzaldehyde was used as an internal standard (ISTD). The selectivity, linearity of calibration, accuracy, intraday and interday precision and forced degradation studies were examined as parts of the method validation. Results: The concentration-response relationship was linear over a concentration range of 0.2-250 μg.mL-1 for acetaminophen, 0.5-250 μg.mL-1 for pseudoephdrine HCI and pheniramine maleate, 1-250 μg.mL-1 for guaifenisin, 2.5-250 μg.mL-1 for chlorpheniramine maleate and triprolidine HCI, 5-250 μg.mL-1 for pyrilamine maleate and diphenhydramine HCI, 10-20 μg.mL-1 for dextromethorphan HBr with correlation coefficients better than 0.9993. The relative standard deviations of the intraday and interday were all less than 4%. Conclusion: The proposed liquid chromatog. method was successfully applied for the routine anal. of these compounds in different cough and cold pharmaceutical preparations such as syrups and tablets. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate
The Article related to reversed phase high performance chromatog, cough cold pharmaceutical active ingredient, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate