Huang, Taomin; Chen, Nianzu; Wang, Donglei; Lai, Yonghua; Cao, Zhijuan published an article in 2014, the title of the article was A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations.Computed Properties of 132-20-7 And the article contains the following content:
Background: A simple, rapid, and accurate stability-indicating reverse phase liquid chromatog. method was developed and validated for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in bulk drugs and pharmaceutical formulations. Results: Optimum chromatog. separations among pheniramine maleate, naphazoline hydrochloride and stress-induced degradation products have been achieved within 10 min by using an Agilent zorbax eclipse XDB C18 column (150 mm × 4.6 mm, 5 μm) as the stationary phase with a mobile phase consisted of 10 mM phosphate buffer pH 2.8 containing 0.5% triethlamine and methanol (68:32, volume/volume) at a flow rate of 1 mL min-1. Detection was performed at 280 nm using a diode array detector. Theor. plates for pheniramine maleate and naphazoline hydrochloride were calculated to be 6762 and 6475, resp. The method was validated in accordance with ICH guidelines with respect to linearity, accuracy, precision, robustness, specificity, limit of detection and quantitation. Regression anal. showed good correlations (R2 > 0.999) for pheniramine maleate in the concentration range of 150-1200 μg mL-1 and naphazoline hydrochloride in 12.5-100 μg mL-1. The method results in excellent separation of both the analytes and degradation products. The peak purity factor is ≥980 for both analytes after all types of stress, indicating complete separation of both analyte peaks from the stress induced degradation products. Conclusions: Overall, the proposed stability-indicating method was suitable for routine quality control and drug anal. of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7
The Article related to naphazoline hydrochloride pharmaceutical formulation quality control rphplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7