Sawant, Sakshi; Borkar, Nitin published an article in 2015, the title of the article was Validation of high performance liquid chromatographic method for the simultaneous determination of common cough and cold ingredients in multicomponent oral drug products.HPLC of Formula: 132-20-7 And the article contains the following content:
This research was done to develop a potential, reliable fast and efficient anal. method for various dosage forms eg. Syrup, tablet, suspension etc which could estimate all the major components of a cough and cold multicomponent formulation and also this method was validated. All common used components like pheniramine maleate, phenylephrine hydrochloride, acetaminohen, dextromethorphan hydrobromide, guafenesin, chlorpheniramine maleate, diphenhydramine in cough and cold category of products also covering more than one dosage forms eg. Syrups, suspensions, tablet etc was used thus making the methodol. by and large universal for the entire range of cough and cold products. This would help in using almost a common method of anal. for separation of most of the components instead of using a lot of sep. methods for the same product or using a common method of anal. for a range of different dosage form of cough and cold category for a common set of components. This would save time and cost and ensure optimum usage of resources. Mobile phase of 0.01M 1-octane sulfonic acid sodium salt monohydrate pH adjusted to 2.80 with 0rthophosphoric acid: Acetonitrile in a gradient ratio was used with a flow rate of 1.0 mL/min on a C18, 25 × 4.6 mm id, 5μ column at a wavelength of 264nm. This method was validated for parameters as accuracy, repeatability, reproducibility, robustness, linearity, limit of detection and limit of quantification. This HPLC method was found to be specific, linear, precise,accurate, reproducible and robust and can be easily used for determination of common cough and cold analytes in a formulation as the results were found to be well within the acceptance range. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7
The Article related to cough cold ingredient high performance liquid chromatog, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.HPLC of Formula: 132-20-7