On July 21, 2022, Gavory, Gerald; Ghandi, Mahmoud; Chicas, Agustin; Warmuth, Markus published a patent.HPLC of Formula: 39919-70-5 The title of the patent was Preparation of isoindolinone compounds for treating Myc-driven cancers with GSPT1 degraders. And the patent contained the following:
The present disclosure relates to new methods to predict the responsiveness of cancer patients to GSPT1 neg. modulators and thus determine the of efficacy GSPT1 neg. modulators to treat cancer patients by determining the level of one or more biomarkers in samples of the patients. The present disclosure also relates to applications of these methods, which includes stratifying cancer malignancies, in particular identifying Myc-driven cancers, and thereby devising optimized and personalized treatments for these cancer patients, as well as optimizing the selection of patient populations for resp. clin. trials. The title compounds I [X1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; or X1 together with X4 forms (un)substituted 4-8 membered heterocycloalkyl; X2 = H, cycloalkyl, aryl, etc.; X3 = NH, O; X4 = NH, CH2; X5 = H, alkyl, alkoxy, CN, etc.; L1 and L2 = (independently) a covalent bond, (un)substituted alkylene; L3 = a covalent bond, O, (un)substituted alkylene, etc.] or pharmaceutically acceptable salts or stereoisomers thereof, were prepared E.g., a multi-step synthesis of II, starting from Me 5-bromo-2-methylbenzoate, was described. Exemplified compounds I were tested for their ability for cereblon binding (data given for representative compounds I). The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).HPLC of Formula: 39919-70-5
The Article related to isoindolinone dioxopiperidinyl preparation cereblon modulator anticancer myc driven cancer, gspt1 degrader modulator biomaker isoindolinone dioxopiperidinyl preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 39919-70-5