Lombardini, J. B.; Props, C. published an article in 1997, the title of the article was Analogs of taurine as inhibitors of the phosphorylation of an ≈20 K molecular weight protein present in a mitochondrial fraction of the rat retina.Computed Properties of 636-73-7 And the article contains the following content:
It was previously demonstrated that taurine inhibits the phosphorylation of a ≈20 K apparent mol. weight protein present in the mitochondrial fraction of the rat retina. Analogs of taurine were tested for their inhibitory activity on the phosphorylation of this 20 K protein. The most potent analogs were (±)trans-2-aminocyclopentanesulfonic acid (TAPS) and 1,2,3,4-tetrahydroquinoline-8-sulfonic acid (THQS), which were 21 and 7 times more potent than the parent compound, taurine, resp. Median-effect plots were used to calculate the inhibitory median effect and combination index values for the combined effects of taurine and taurine analogs. It was determined that the inhibitory taurine analogs were antagonistic to taurine when used in combination with taurine to inhibit the phosphorylation of the 20 K apparent mol. weight protein. It was concluded that the distance between the N and S atoms in the taurine structure was important for inhibitory activity. If the N atom was either within or attached to an unsaturated ring structure, the inhibitory potency was decreased. If both the S and N atoms were present within the ring structure, the analog has no activity. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7
The Article related to retina protein phosphorylation inhibition taurine analog, General Biochemistry: Subcellular Processes and other aspects.Computed Properties of 636-73-7