On August 31, 2010, Phatthiyaphaibun, K.; Som-Aum, W.; Srisa-ard, M.; Threeprom, J. published an article.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Chiral separation of pheniramine by capillary electrophoresis partial-filling technique using hydroxypropyl-β-cyclodextrin as chiral selector. And the article contained the following:
A simple capillary electrophoresis partial-filling technique for the enantioseparation of pheniramine is presented. Phosphate buffer and hydroxypropyl-β-cyclodextrin (HP-β-CD) were used as the electrolyte and chiral selector, resp. Several exptl. parameters such as HP-β-CD concentration, HP-β-CD plug length, CE temperature and applied voltage were studied. Under the selected conditions, pheniramine enantiomers can be separated within <14 min. The assay was validated for linearity (5.0 × 10-6 - 5.0 × 10-4 M; R2 = 0.9987), limit of detection (5.0 × 10-7 M), limit of quantitation (5.0 × 10-6 M), anal. precision (%RSD ≤ 9.8) and accuracy (%recovery = 101 ± 3). The proposed methodol. was then applied to the anal. of a com. available pharmaceutical eye drop preparation The results are in good agreement with that declared by the manufacturer. The proposed methodol. provides adequate results in terms of simplicity, cost, sample throughput, repeatability and accuracy for quality control of pheniramine enantiomers in pharmaceutical preparations The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate
The Article related to pheniramine enantiosepn capillary electrophoresis partial filling technique hydroxypropylcyclodextrin selector, Organic Analytical Chemistry: Separations and other aspects.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate