On January 15, 1980, Freyne, Eddy J.; Esmans, Eddy L.; Lepoivre, Josef A.; Alderweireldt, Frank C. published an article.Name: 5-Isopropylnicotinic acid The title of the article was Stereospecific synthesis of a novel series of pyridine nucleosides. And the article contained the following:
Condensation of 3,5-di-O-benzoyl-β-D-ribofuranosyl chloride severally with 3-acetyl-5-alkylpyridines, 5-alkyl-3-methoxycarbonylpyridines (alkyl = Me, Et, Pr, and Me2CH), 5-isopropylnicotinamide, and 3,5-diacetylpyridine bis(ethylene acetal) in MeCN at -5° gave the corresponding 1-(3,5-di-O-benzoyl-β-D-ribofuranosyl)-3,5-disubstituted pyridinium chlorides in excellent yield (90%). From the reaction of a series of 2,3-O-isopropylidene-β-D-ribofuranosyl halides with 3-acetyl-5-methylpyridine at room temperature, the α-nucleosides were obtained. The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Name: 5-Isopropylnicotinic acid
The Article related to pyridine nucleoside, stereospecific ribosylation pyridine, Carbohydrates: Nucleosides, Nucleotides and other aspects.Name: 5-Isopropylnicotinic acid