Madura, J. D.; Lombardini, J. B.; Briggs, J. M.; Minor, D. L.; Wierzbicki, A. published an article in 1997, the title of the article was Physical and structural properties of taurine and taurine analogs.Formula: C5H5NO3S And the article contains the following content:
The inhibition of the phosphorylation of an ∼20kDa protein present in the mitochondrial fraction of the rat retina by taurine and taurine analogs was investigated using computational methods. Correlations between mol. weight, mol. volume, and calculated pKa values vs. IC50 values are reported. These data appear to support the hypotheses according to Lombardini and Props that the inhibition of the phosphorylation of an ∼20 kDa protein by taurine and taurine analogs dependent on (i) the critical distance between the N and S atoms in the taurine moiety (S-C-C-N) of the analog, (ii) the environment of the N atom in the taurine analog (saturated ring vs. unsaturated ring), and (iii) the placement of both the S and N atoms not being present simultaneously in the ring structure. Using computational methods results supporting hypotheses (i) and (ii) are presented. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Formula: C5H5NO3S
The Article related to taurine qsar protein phosphorylation inhibition retina, Mammalian Biochemistry: Metabolism and other aspects.Formula: C5H5NO3S