Balzarini, J.; De Clercq, E. published an article in 1982, the title of the article was Structure-function relationship of the antitumor cell activity of pyrimidine and pyridine derivatives.Recommanded Product: 73591-69-2 And the article contains the following content:
Fifty-two 2′-deoxyuridines, 10 2′-deoxycytidines, uracil arabinoside [3083-77-0] and 7 analogs, cytosine arabinoside [147-94-4] and 7 analogs, 5 nicotinic acid analogs, and 4 nicotinamide analogs were compared for their inhibitory effects on murine leukemia (L1210) cell growth. The most dramatic antitumor activity was demonstrated by the deoxyuridine analogs containing a small C5-substituent with high electron-withdrawing potency, i.e., F-, CF3-, ethynyl, or formyl. The deoxycytidine analogs were generally less active, with the 5-nitro- [69100-02-3] and 5-ethynyl [69075-47-4] analogs having the greatest effect. Of the 5-substituted uracil arabinosides, only the 5-Me analog [605-23-2] significantly inhibited L1210 growth. Cytosine arabinoside and its 5-fluoro analog [4298-10-6] were highly effective inhibitors. Of the nicotinic acid derivatives, only the m-propyl- [73591-68-1] and m-isopropyl [73591-69-2] derivatives showed weak antitumor activity. The meta- and para-alkylated nicotinamide derivatives also had weak activity. The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Recommanded Product: 73591-69-2
The Article related to antitumor pyridine pyrimidine derivative structure, structure activity pyridine pyrimidine derivative, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 73591-69-2