Reference of 16063-69-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16063-69-7 as follows.
2,4,6-Trichloropyridine (20.0 g, 190.63 mmol) was dissolved ethanol (100 mL). Methyl amine (33% wt in ethanol, 81.9 mL, 657 mmol) was added dropwise and the reaction mixture was stirred at room temperature for 2 weeks. The white precipitate was filtered off and washed with te/t-butylmethylester and water to give (2,6-dichloro- pyhdin-4-yl)-methylamine (11.9 g, 61 %) as a white crystalline compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16063-69-7, its application will become more common.
Reference:
Patent; NeuroSearch A/S; WO2008/92942; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem