On December 16, 1971, Nicolson, Adrian published a patent.Application of 34968-33-7 The title of the patent was Chlorofluoropyridines. And the patent contained the following:
The title compounds were prepared by fluorination of chloropyridines with KF or NaF in a nonhydroxylic solvent, e.g. tetramethylene sulfone (I) or AcNMe2, in the presence of alcs., acids, or bases, e.g. MeOH, HO(CH2)2OH, glycerol, EtCO2H, or Bu3N. Thus, pentachloropyridine was added to KF (1:5.7 mole %) in I. ClCH2CO2H was added and the mixture refluxed 2 hr to give 79% fluorinated pyridines consisting of 3,5-dichlorotrifluoropyridine 97.5, pentafluoropyridine+3-chlorotetrafluoropyridine 2.2, and 3,5,6-tri-chlorodifluoropyridine 0.4%. Similarly prepared were 4-chloro-2-fluoro-, 2-chloro-4-fluoro-, 2,4-difluoro-, 6-chloro-2,4-difluoro,-and 4-chloro-2,6-difluoropyridine. The experimental process involved the reaction of 4-Chloro-2,6-difluoropyridine(cas: 34968-33-7).Application of 34968-33-7
The Article related to chlorofluoropyridine preparation, fluorochloropyridine preparation, pyridine chlorofluoro preparation, fluorination and other aspects.Application of 34968-33-7