In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13534-97-9, name is 6-Bromopyridin-3-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 13534-97-9
To a stirred solution of 6-bromopyridin-3-amine (2.0 g, 11.56 mmol) in DCM (50 mL), 2-phenylacetic acid (2.04 g, 15.02 mmol), and TEA (4.60 g, 46.24 mmol) were added, followed by the addition of T3P (9.19 g, 28.90 mmol) at 0C. The resulting mixture was stirred at rt for 16 h. The reaction mixture was washed with saturated NaHCOs aqueous solution (100 mL). The organic layer was dried over anhydrous Na2S04 and filtered. The filtered solution was concentrated under reduced pressure and the resulting crude compound was purified by flash column chromatography using 25% ethyl acetate in pet ether as eluent to afford the title compound (2,30 g, 68%) as an off-white solid.LC-MS (method 1): Rt = 2.46 min; m/z = 291.08 (M+H+).
The synthetic route of 13534-97-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ORYZON GENOMICS, S.A.; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; SALAS SOLANA, Jorge; (103 pag.)WO2019/110663; (2019); A1;,
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