《Aza-Henry Reaction: Synthesis of Nitronaphthylamines from 2-(Alkynyl)benzonitriles》 was written by Verma, Shalini; Kumar, Manoj; Verma, Akhilesh K.. Reference of 2-Bromonicotinaldehyde And the article was included in Organic Letters in 2020. The article conveys some information:
A transition-metal-free approach for construction of nitronaphthylamines has been developed for the first time through aza-henry, chemoselective, and regioselective annulation of 2-alkynylbenzonitriles with nitromethane. In addition, the strategy provides an elegant, operationally simple and atom-economical route for the synthesis of nitroamino substituted heterocyclic scaffolds, featuring a range of sensitive functional groups. The reaction could also devise acetonitrile and acetophenone as nucleophile. The protocol has been successfully implemented for late-stage modification of bioactive mols.2-Bromonicotinaldehyde(cas: 128071-75-0Reference of 2-Bromonicotinaldehyde) was used in this study.
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Reference of 2-Bromonicotinaldehyde