The author of 《A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages》 were Lucy, Daniel; Purvis, Gareth S. D.; Zeboudj, Lynda; Chatzopoulou, Maria; Recio, Carlota; Bataille, Carole J. R.; Wynne, Graham M.; Greaves, David R.; Russell, Angela J.. And the article was published in ACS Chemical Biology in 2019. Related Products of 103-74-2 The author mentioned the following in the article:
GPR84 is an orphan G-protein-coupled receptor that is expressed on immune cells and implicated in several inflammatory diseases. The validation of GPR84 as a therapeutic target is hindered by the narrow range of available chem. tools and consequent poor understanding of GPR84 pathophysiol. Here we describe the discovery and characterization of DL-175, a potent, selective, and structurally novel GPR84 agonist and the first to display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, and human U937 cells. By comparing DL-175 with reported GPR84 ligands, we show for the first time that biased GPR84 agonists have markedly different abilities to induce chemotaxis in human myeloid cells, while causing similar levels of phagocytosis enhancement. This work demonstrates that biased agonism at GPR84 enables the selective activation of functional responses in immune cells and delivers a high-quality chem. probe for further investigation. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 103-74-2