COA of Formula: C5H5BrN2On November 20, 2020 ,《I(III)-Catalyzed Oxidative Cyclization-Migration Tandem Reactions of Unactivated Anilines》 appeared in Organic Letters. The author of the article were Deng, Tianning; Shi, Emily; Thomas, Elana; Driver, Tom G.. The article conveys some information:
An I(III)-catalyzed oxidative cyclization-migration tandem reaction using Selectfluor as the oxidant was developed that converts unactivated anilines into 3H-indoles is reported herein. The reaction requires as little as 1 mol % of the iodocatalyst and is mild, tolerating pyridine and thiophene functional groups, and the dependence of the diastereoselectivity of the process on the identity of the iodoarene or iodoalkane precatalyst suggests that the catalyst is present for the stereochem. determining C-N bond forming step. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1COA of Formula: C5H5BrN2)
2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.COA of Formula: C5H5BrN2