Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1104455-41-5, name is Methyl 4-chloro-5-methylpicolinate. A new synthetic method of this compound is introduced below., Product Details of 1104455-41-5
A mixture of methyl 4-chloro-5-methylpyridine-2-carboxylate (200 mg, 1.08 mmol), 1- cyclopropyl-4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrazole (302.7 mg, 1.29 mmol), Pd(dppf)Cl2-CH2Cl2 (88.0 mg, 0.11 mmol), and K2CO3 (446.8 mg, 3.23 mmol) in dioxane (4 mL) and water (1 mL) was stirred at 80 C for 2 h under nitrogen atmosphere. After cooling to room temperature, the residue was purified by reverse phase flash 33 chromatography with 40-70% MeCN in H2O to afford compound l3-a (60 mg, 21.64%) as a yellow solid.
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Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WANG, Guoqiang; SHEN, Ruichao; GRANGER, Brett; HE, Jing; XING, Xuechao; HE, Yong; LONG, Jiang; MA, Jun; WANG, Bin; OR, Yat, Sun; (99 pag.)WO2019/213244; (2019); A1;,
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