Liang, Yuru; Zhang, Mao; Zhou, Pengfei; Liu, Mingming; Li, Jianqi; Wang, Yang published their research in Bioorganic Chemistry in 2021. The article was titled 《Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors》.Quality Control of 2,5-Dibromopyridine The article contains the following contents:
A novel class of diaryl substituted azetidin-2-one derivatives were designed, asym. synthesized, and evaluated for antiproliferative activities. The in vitro antitumor assay revealed that among the 4-aryl-substituted 1-(3,4,5-trimethoxyphenyl)azetidin-2-ones (B series), most possessed moderate to strong activities, with compound B7c that bears a 2-naphthyl substituent being the most potent one (IC50 0.16-0.40 μM) against a panel of human cancer cell lines. In contrast, none of the 3-(arylmethylene)-substituted 1-(3,4,5-trimethoxyphenyl)azetidin-2-ones (L series) showed significant activities in the assay. Further studies indicated that B7c inhibited tubulin polymerization, disrupted in vitro vascularization, blocked cell cycle progression at G2/M phase, induced cell apoptosis, decreased mitochondrial membrane potential, and increased the intracellular reactive oxygen species level in a dose-dependent way. Compound B7c also inhibited significantly tumor growth in a xenograft mice model with no obvious drop in the mice body weights Collectively, these results suggested that B7c and its analogs should merit further investigation as new promising antitumor agents. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Quality Control of 2,5-Dibromopyridine)
2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 2,5-Dibromopyridine