《Access to 2-Alkyl/Aryl-4-(1H)-Quinolones via Orthogonal “”NH3″” Insertion into o-Haloaryl Ynones: Total Synthesis of Bioactive Pseudanes, Graveoline, Graveolinine, and Waltherione F》 was written by Singh, Shweta; Nerella, Sharanya; Pabbaraja, Srihari; Mehta, Goverdhan. Category: pyridine-derivatives And the article was included in Organic Letters in 2020. The article conveys some information:
An efficient one-pot synthesis of 4-(1H)-quinolones through an orthogonal engagement of diverse o-haloaryl ynones with ammonia in the presence of Cu(I), involving tandem Michael addition and ArCsp2-N coupling, is presented. The substrate scope of this convenient protocol, wherein ammonium carbonate acts as both an in situ ammonia source and a base toward diverse 2-substituted 4-(1H)-quinolones, has been mapped and its efficacy validated through concise total synthesis of bioactive natural products pseudanes (IV, VII, VIII, and XII), graveoline, graveolinine, and waltherione F. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Category: pyridine-derivatives)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives