《The Synthesis of Primary Amines through Reductive Amination Employing an Iron Catalyst》 was published in ChemSusChem in 2020. These research results belong to Baeumler, Christoph; Bauer, Christof; Kempe, Rhett. Related Products of 1122-54-9 The article mentions the following:
Iron-catalyzed synthesis of primary amines through reductive amination was realized. A broad scope and a very good tolerance of functional groups were observed Ketones, including purely aliphatic ones, aryl-alkyl, dialkyl, and heterocyclic, as well as aldehydes were converted smoothly into their corresponding primary amines. In addition, the amination of pharmaceuticals, bioactive compounds, and natural products was demonstrated. Many functional groups, such as hydroxy, methoxy, dioxol, sulfonyl, and boronate ester substituents, were tolerated. The catalyst is easy to handle, selective, and reusable and ammonia dissolved in water could be employed as the nitrogen source. The key feature of this method includes the use of a specific Fe complex for the catalyst synthesis and an N-doped SiC material as catalyst support. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1122-54-9