In 2017,Tsupova, Svetlana; Cadu, Alban; Stuck, Fabian; Rominger, Frank; Rudolph, Matthias; Samec, Joseph S. M.; Hashmi, A. Stephen K. published 《Dual Gold(I)-catalyzed Cyclization of Dialkynyl Pyridinium Salts》.ChemCatChem published the findings.HPLC of Formula: 128071-75-0 The information in the text is summarized as follows:
Novel dialkynyl pyridines were synthesized and protected as alkyl salts for dual gold(I)-catalyzed cycloisomerization. Different alkyl groups and counter ions were screened for the salts, with benzyl and hexafluorophosphate providing the best results. The cyclization led to NMR yields of >95% being obtained for a number of substrates. Step-wise hydrogenation of products was performed in one-pot by Pd/C, with selective reduction of the double bonds, followed by deprotection of the benzyl group. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 128071-75-0