《Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions》 was written by Song, A-Xiang; Zeng, Xiao-Xiao; Ma, Bei-Bei; Xu, Chang; Liu, Feng-Shou. Synthetic Route of C5H3BrClNThis research focused onunsym palladium heterocyclic carbene PEPPSI complex preparation arylation catalyst; crystal structure unsym palladium heterocyclic carbene PEPPSI type complex; mol structure unsym palladium heterocyclic carbene PEPPSI type complex; palladium carbene catalyzed heteroarylation heteroarene; muscle relaxant drug dantrolene conjugated mesopolymer preparation. The article conveys some information:
With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsym. Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The use of this unsym. strategy led to much higher efficiency in comparison to the commonly used C2-sym. Pd-PEPPSI-type NHC complexes. Also, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at ≥0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with the authors’ study, also the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Synthetic Route of C5H3BrClN)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Synthetic Route of C5H3BrClN