As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 886365-43-1, name is 5-Bromo-3-methylpicolinic acid, molecular formula is C7H6BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C7H6BrNO2
To a solution of compound 7 (4.9 g, 22.68 mmol) in C2H5OH(20 mL) was added H2SO4 (2.2 g, 22.68 mmol) at room temperature.The mixture was heated at 80 C for 8 h. Solvent was concentrated invacuo and EtOAc (200 mL) was added. After washed with water(100 mL¡Á3), the organic phase was dried over Na2SO4, filtered andconcentrated in vacuo. The residue was purified by flash columnchromatography (silica gel, petroleum ether/EtOAc=20/1) to affordethyl 5-bromo-3-methylpicolinate (8, 4.6 g, 83%) as colorless liquid. 1HNMR (300 MHz, DMSO-d6) delta (ppm): 8.62 (s, 1H), 8.14 (s, 1H), 4.34 (q,J=7.1 Hz, 2H), 2.45 (s, 3H), 1.32 (t, J=7.1 Hz, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 886365-43-1.
Reference:
Article; Yuan, Xinrui; Wu, Hanshu; Bu, Hong; Zheng, Peiyuan; Zhou, Jinpei; Zhang, Huibin; Bioorganic and Medicinal Chemistry; vol. 27; 7; (2019); p. 1211 – 1225;,
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