In 2014,Lafaye, Kevin; Nicolas, Lionel; Guerinot, Amandine; Reymond, Sebastien; Cossy, Janine published ãLewis Basicity Modulation of N-Heterocycles: A Key for Successful Cross-Metathesisã?Organic Letters published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:
Introducing a chloro or other substituent neighboring the nitrogen atom of azaheterocycle-containing alkenes decreased their Lewis basicity sufficiently that, in most cases, they underwent olefin cross-metathesis with alkenes such as Me acrylates and (Z)-2-butene-1,4-diol diacetate in the presence of the second-generation Hoveyda-Grubbs ruthenium metathesis catalyst to give azaheteroaryl-substituted alkenes diastereoselectively. A variety of electron-deficient and electron-rich olefins and styrenes underwent metathesis, while chloro-, bromo-, fluoro-, trifluoromethyl-, trifloxy-, methoxy-, and tert-butyl-substituted pyridinylalkenes and chloro-substituted pyrimidinyl, isoquinolinyl, imidazolyl, and pyrazolyl alkenes were effective metathesis substrates. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 5-Bromo-2-chloropyridine