Related Products of 1513-66-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1513-66-2, name is 2,3-Difluoropyridine, molecular formula is C5H3F2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 4-cyano-piperidine-1-carboxylic acid tert-butyl ester (200 mg, 0.95 mmol) in DMF (2 mL) was added to a stirred solution of KHMDS (0.5 M in hexane, 1.9 mmol). After 5 min, a solution of 2,3-difluoropyridine (0.13 g, 1.14 mmol) in DMF (2 mL) was added and stirred for additional 2 h under nitrogen atmosphere. DMF was evaporated in vacuo. The resulting crude product was extracted with EtOAc and the extracts were successively washed with water and brine, and the organic layer was evaporated and subjected to column chromatography (50% Ethyl acetate/hexane) to provide the title Compound. 1H NMR (d6-DMSO, 300 MHz) delta 1.40 (m, 9H), 2.18 (m, 4H), 3.20 (m, 2H), 4.15 (m, 2H), 7.28 (m, 1H), 7.42 (m, 1H), 8.34 (m, 1H); MS (ESI) m/z=307 (MH+).
According to the analysis of related databases, 1513-66-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Genelabs Technologies, Inc.; US2010/204265; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem