Safety of 2-(2-Hydroxyethyl)pyridineIn 2021 ,ãTitanium Complexes with Functional Alkoxido Ligands for Selective Ethylene Dimerization – A High Throughput Experimentation Approachã?appeared in ChemCatChem. The author of the article were Grasset, Fabien L.; Welter, Richard; Braunstein, Pierre; Olivier-Bourbigou, Helene; Magna, Lionel. The article conveys some information:
New titanium complexes of general formula [Ti(OR)2(OiPr)2], containing functionalized alkoxido ligands, were developed for the selective catalytic dimerization of ethylene to 1-butene using a combined High Throughput Screening (HTS) / Design of Experiment (DoE) approach. First, a library of 19 ligands was elaborated and a primary screening spotted the phosphorus-functionalized alkoxido ligands as most promising. A second, more focused library containing 8 alkoxidophosphine ligands was then developed. A longer linear spacer between the alkoxido and the phosphorus functions, as in [Ti(19)2(OiPr)2], was found beneficial for this catalytic reaction. After identification of the best co-catalyst (AlEt3) and co-ligand (OBu), final optimization of the reaction conditions was performed using a design of experiments (DoE) approach. The complex [Ti(19)2(OBu)2] was shown to selectively dimerize ethylene in 1-butene (C4(α)=93% (99+%)) at 30 bar C2H4 and 55° with AlEt3 as co-catalyst, resulting in very high activity and selectivity for a mol. titanium catalyst (13000 g gTi-1 h-1, 93% 1-butene). In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 2-(2-Hydroxyethyl)pyridine