Anekthanakul, Krittima; Manocheewa, Siriphan; Chienwichai, Kittiphan; Poungsombat, Patcha; Limjiasahapong, Suphitcha; Wanichthanarak, Kwanjeera; Jariyasopit, Narumol; Mathema, Vivek Bhakta; Kuhakarn, Chutima; Reutrakul, Vichai; Phetcharaburanin, Jutarop; Panya, Atikorn; Phonsatta, Natthaporn; Visessanguan, Wonnop; Pomyen, Yotsawat; Sirivatanauksorn, Yongyut; Worawichawong, Suchin; Sathirapongsasuti, Nuankanya; Kitiyakara, Chagriya; Khoomrung, Sakda published an article in 2021. The article was titled ãPredicting lupus membranous nephritis using reduced picolinic acid to tryptophan ratio as a urinary biomarkerã? and you may find the article in iScience.Application In Synthesis of Picolinic acid The information in the text is summarized as follows:
The current gold standard for classifying lupus nephritis (LN) progression is a renal biopsy, which is an invasive procedure. Undergoing a series of biopsies for monitoring disease progression and treatments is unlikely suitable for patients with LN. Thus, there is an urgent need for non-invasive alternative biomarkers that can facilitate LN class diagnosis. Such biomarkers will be very useful in guiding intervention strategies to mitigate or treat patients with LN. Urine samples were collected from two independent cohorts. Patients with LN were classified into proliferative (class III/IV) and membranous (class V) by kidney histopathol. Metabolomics was performed to identify potential metabolites, which could be specific for the classification of membranous LN. The ratio of picolinic acid (Pic) to tryptophan (Trp) ([Pic/Trp] ratio) was found to be a promising candidate for LN diagnostic and membranous classification. It has high potential as an alternative biomarker for the non-invasive diagnosis of LN. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application In Synthesis of Picolinic acid