Joshi, Arti; Gupta, Ruby; Sharma, Deepika; Singh, Monika published an article in 2021. The article was titled ãA Mo(VI) based coordination polymer as an antiproliferative agent against cancer cellsã? and you may find the article in Dalton Transactions.Recommanded Product: Picolinic acid The information in the text is summarized as follows:
Metal ions being an important part of biol. systems are of great interest in the designing of new drugs. Molybdenum is an essential trace element for humans, animals, and plants and naturally present in many enzymes hence its complexes can be expected to serve as potential candidates for biomedical applications. A novel molybdenum-based coordination polymer, [Mo2(μ2-O)O4(2-pyc)2(H2O)], is synthesized by a hydrothermal route and structurally characterized by using single crystal X-Ray diffraction. The structure consists of molybdenum octahedra connected by a bridging oxo ligand and 2-pyc forming a one-dimensional coordination polymer. This Mo coordination polymer was found to show a considerable inhibitory effect with IC50 values of 22.63 μmol L-1, 28.19 μmol L-1, and 20.97 μmol L-1, against HepG2 (human liver cancer), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines resp. This is the first attempt at exploring the molybdenum-based coordination polymer for antitumor applications. The cell cytotoxicity anal. revealed that the anti-tumor potential of the compound is governed by arresting of the A549, HepG2, and MCF-7 cancer cells in the S phase of the cell cycle. UV-Visible absorption spectroscopy further revealed the binding interaction between the Mo coordination polymer and ctDNA and the binding constant was found to be 5.9 x 103 L mol-1, which is in agreement with those of well-known groove binders. This binding interaction in turn induces apoptosis and necrosis pathways leading to the death of the cancer cells.Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid) was used in this study.
Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid