Nemeth, Andras Gy.; Szabo, Renata; Orsy, Gyorgy; Mandity, Istvan M.; Keseru, Gyorgy M.; Abranyi-Balogh, Peter published an article in 2021. The article was titled ãContinuous-flow synthesis of thioureas, enabled by aqueous polysulfide solutionã? and you may find the article in Molecules.Synthetic Route of C5H5BrN2 The information in the text is summarized as follows:
The continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur was developed. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur. In the experiment, the researchers used many compounds, for example, 6-Bromopyridin-3-amine(cas: 13534-97-9Synthetic Route of C5H5BrN2)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (RâCâ¡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CHâNHRâ? to form imines (R2C=NRâ?. Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C5H5BrN2