Chung, Hyunho; Kim, Jeongyun; Gonzalez-Montiel, Gisela A.; Ha-Yeon Cheong, Paul; Lee, Hong Geun published an article in 2021. The article was titled ãModular Counter-Fischer-Indole Synthesis through Radical-Enolate Couplingã? and you may find the article in Organic Letters.Application In Synthesis of 4-Acetylpyridine The information in the text is summarized as follows:
A single-electron transfer mediated modular formation of indoles e.g., 2-phenyl-1H-indole from a 2-iodoaniline derivatives 2-I-3-R-4-R1-5-R2-6-R3C6NH(R4) [R = H, Cl, Br; R1 = H, Me, CN, Br, (tert-butoxy)carbonyl, etc.; R2 = H, Me, OMe, Cl, Br; R3 = H, Cl, Br; R4 = H, Me, Bn, 1-hexyl, cyclohexyl; R2R3 = -CH=CHCH=CH-] and a ketones e.g., acetophenone has been developed. This transition-metal-free reaction shows a broad substrate scope and unconventional regioselectivity trends. Moreover, important functional groups for further transformation are tolerated under the reaction conditions. D. functional theory studies reveal that the reaction proceeds by metal coordination, which converts a disfavored 5-endo-trig cyclization to an accessible 7-endo-trig process. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Application In Synthesis of 4-Acetylpyridine)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 4-Acetylpyridine